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Description

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1

Each works independently without concern about blood flow interference

A prediction of the intramolecular handover model is that the YY mutations in the GD would impair AAGABs binding to not only 2 but also , due to the role of the YY motif in mediating the attachment of the :2 hemicomplex to the GD of AAGAB